Savesto 50 is a starting-dose angiotensin receptor-neprilysin inhibitor (ARNI) combination used for the treatment of chronic heart failure with reduced ejection fraction (HFrEF) in adults. This 50mg tablet (containing Sacubitril 24mg + Valsartan 26mg) is typically used to initiate therapy, especially in patients transitioning from lower doses of ACE inhibitors or ARBs, or in those who may be sensitive to hypotension. It provides the dual neurohormonal action of neprilysin inhibition and angiotensin II receptor blockade, forming the foundation for uptitration to higher, more effective doses.

• Starting Dose for Safe Initiation: Allows for careful introduction of ARNI therapy with a lower risk of initial side effects like hypotension.
  
• Dual-Action Foundation: Begins the process of comprehensive neurohormonal blockade crucial for heart failure management.
  
• Enables Dose Titration: Serves as the first step in reaching the target therapeutic dose for optimal heart failure control.
  

Composition
Each film-coated tablet contains:

• Sacubitril: 24 mg
  
• Valsartan: 26 mg
  (as sacubitril valsartan sodium salt complex)

Directions for Use

• Use only as directed by the physician.

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